{"action":"create","ckan_id":null,"date_created":"Mon, 30 Mar 2026 23:00:19 GMT","date_finished":null,"harvest_job_id":"06a31c36-ed4b-4bbd-b10a-13180d62bd8f","harvest_source_id":"bebdce30-696c-424b-ad16-eca2913bde29","id":"2383aee3-74f6-42af-a4d1-ccb1aaddcc93","identifier":"https://data.cdc.gov/api/views/hcxx-dqtx","parent_identifier":null,"source_hash":"bf43b4cf78776fa3e20c3f3fc1dcea80508bbf64845fbc9f60a0a326dc6f0981","source_raw":"{\"@type\": \"dcat:Dataset\", \"accessLevel\": \"public\", \"bureauCode\": [\"009:20\"], \"contactPoint\": {\"@type\": \"vcard:Contact\", \"fn\": \"Health Effects Laboratory Research, Toxicology and Molecular Biology Branch\", \"hasEmail\": \"mailto:sa-cin-webteam@cdc.gov\"}, \"description\": \"Exposure to certain engineered nanomaterials (ENMs) causes chronic lesions like lung fibrosis and cancer as a result of unresolved inflammation. Elucidating how ENM-induced inflammation is resolved is necessary for better evaluation of the fibrogenic and tumorigenic potentials of ENMs. This study aimed to identify pro-resolving mechanisms by analyzing the inflammatory and fibrogenic responses to multi-walled carbon nanotubes (MWCNTs, Mitsui-7) and fullerenes (fullerene C60, C60F) in B6C3F1 mice. The findings reveal that MWCNTs at a low dose (40 \\u00b5g/mouse) and C60F at a high dose (>480 mg/mouse) stimulated acute neutrophilic inflammation, which exhibited rapid initiation and extended resolution. The lesion in MWCNT-exposed mice progressed to fibrotic granulomas by day 28 post-exposure, whereas it remained as alveolar histiocytosis in C60F-exposed mice. The ENMs induced high levels of proinflammatory lipid mediators leukotriene B4 (LTB4) and prostaglandin E2 (PGE2) with peaks at day 1, and high levels of special\", \"distribution\": [{\"@type\": \"dcat:Distribution\", \"downloadURL\": \"https://data.cdc.gov/download/hcxx-dqtx/application/x-zip-compressed\", \"mediaType\": \"application/x-zip-compressed\"}], \"identifier\": \"https://data.cdc.gov/api/views/hcxx-dqtx\", \"issued\": \"2024-11-14\", \"landingPage\": \"https://data.cdc.gov/d/hcxx-dqtx\", \"license\": \"http://opendefinition.org/licenses/odc-odbl/\", \"modified\": \"2026-01-14\", \"programCode\": [\"009:034\"], \"publisher\": {\"@type\": \"org:Organization\", \"name\": \"Centers for Disease Control and Prevention\"}, \"theme\": [\"National Institute for Occupational Safety and Health\"], \"title\": \"Resolution of Pulmonary Inflammation Induced by Carbon Nanotubes and Fullerenes in Mice: Role of Macrophage Polarization\"}","source_transform":null,"status":"error"}